The reusable clip applier consists of jaw, shaft, rotation knob, trigger and fixed handle, and they have 3 different sizes: ML, L, XL. They should be used together with the disposable ligating clips during the procedure.The disposable polymer clips vet only are made of polymer. They have 3 different sizes: S-V, M-V, L-V. They should be used together with the reusable clip applier during the procedure. 6pcs of ligating clips are loaded in one cartridge.